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The

Nano-Safety Research Group

Specialists in the assessment of nanomaterial toxicity to human health and the environment

ENPRA

ENPRA: Risk assessment of engineered nanoparticles

Staff: Vicki Stone, and Ali Kermanizadeh 

 

Funding: FP7

 

Project Aims

To generate exposure and hazard data for panel of ten nanomaterials differing in characteristics in order to deliver a risk assessment. Our role focused on evaluating the toxicity of nanomaterials to the liver and the kidneys, and in the identification of the mechanisms underlying any adverse effects that are observed.

 

Project website:http://enpra.eu/

Project Partners:

  • Institute of Occupational Medicine (UK)
  • Napier University (UK)
  • University of Edinburgh (UK)
  • Université Paris Diderot (France)
  • CEA-CNRS (OMNT) (France)
  • Université Catholique de Louvain (Belgium)
  • Katholieke Universiteit Leuven (Belgium)
  • Vrije Universiteit Busserl (Belgium)
  • Helmholtz Zentrum München - German Research  Center for Environmental Health (Germany)
  • Institut für umweltmedizinische Forschung (Germany)
  • University of Copenhagen (Denmark)
  • National Research Centre for the Working Environment (Denmark)
  • Universita Ca' Foscari di Venezia (Italy)
  • Joint Research Centre (pan-EU)
  • Rijksinstituut voor Volksgezondheid en Milieu (Netherlands)
  • University of Rochester (USA)
  • Duke University (USA)
  • US Environment Protection Agency (USA)
  • National Institute of Occupational Safety & Health (USA)
  • National Institutes of Health - National Institute of Environmental Health Sciences (USA)
  • The Woodrow Wilson Center (USA)

Related publications:

  • Kermanizadeh A, Gaiser BK, Hutchison GR, Stone V. (2012). An in vitro liver model – assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanoparticles. Particle and Fibre Toxicology 9(1):28
  • Kermanizadeh A, Gaiser BK, Ward MB, Stone V. (2012) Primary human hepatocytes vs. hepatic cell line – assessing their suitability for in vitro nanotoxicology. Nanotoxicology [Early Online access]
  • Kermanizadeh A, Gaiser BK, Ward MB, Stone V. (2012). Primary human hepatocytes versus hepatic cell line: assessing their suitability for in vitro nanotoxicology. Nanotoxicology. [Epub ahead of print]
  • Kermanizadeh A, Pojana G, Gaiser BK, Birkedal R, Bilanicova D, Wallin H, Jensen KA, Sellergen B, Hutchison GR, Marcomini A, Stone V. (2013). In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers. Nanotoxicology 7:301-13.
  • Kermanizadeh A, Vranic S, Boland S, Moreau K, Baeza-Squiban A, Gaiser BK, Andrzejczuk LA,Stone V. (2013). An in vitro assessment of panel of engineered nanomaterials using a human renal cell line: cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity. BMC Nephrol.14:96.

Enpra hepatocyte website SMALL

Nanomaterial uptake by the C3A hepatocyte cell line, imaged using TEM