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The

Nano-Safety Research Group

Specialists in the assessment of nanomaterial toxicity to human health and the environment

INLIVETOX

 

InLiveTox: Toxicity of Ingested Nanoparticles

Staff: Vicki Stone, and Birgit Gaiser 

Funding: FP7

Project Aims:

To generate alternatives for animal testing that can assess the hazard of ingested nanomaterials. In particular, this project focuses on developing a fluidic based in vitro test system that will model the response of cells and tissues to the ingestion of nanomaterials using the GIT, endothelium and liver as target systems. Our role is to determine the baseline toxicity of specific nanomaterials in each cell type individually and then in combination, and to evaluate whether in vitro systems were able to predict the in vivo response to ingested nanomaterials.

Project website: http://www.inlivetox.eu/

Project Partners

  • CSEM - Centre Suisse d’Electronique et de Microtechnique (Switzerland)
  • UNIPI - Università di Pisa (Italy)
  • USAAR - Universität des Saarlandes (Germany)
  • HMGU - Helmholtz Zentrum München (Germany)
  • KIRKSTALL - Kirkstall Ltd (UK)
  • URMC - University of Rochester (USA)
  • ALMA - ALMA Consulting Group SAS (France)

Related Publications

  • Gaiser BK, Brown DM, Stone V. Quality control in in vitro nanoparticle testing: Collagen coating can optimise particle distribution on adherent cell lines and improve data quality. “Modern Polymeric Materials for Environmental Applications”, Vol. 4 (Ed. K. Pielichowski), WNT Teza, Krakow 2010 (ISBN 978-83-930641-1-3).
  • Gaiser BK, Collnot E-M, Ucciferri N, Ahluwalia A, Stone V. In vitro risk assessment of nanoparticles. New developments in cell-based in vitro testing. (Book Chapter) 

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