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Nano-Safety Research Group

Specialists in the assessment of nanomaterial toxicity to human health and the environment


PARTICLE_RISK: Risk assessment of exposure to particles

Staff: Helinor Johnston and Vicki Stone


Project Aim

This project was responsible for assessing the health risks associated with exposure to nanomaterials. The adverse effects of a particle panel, that had varied physico-chemical characteristics, was assessed at different target sites in order to identify the physical and chemical characteristics of particles that confer toxicity.Our role was to assess impact of nanomaterial exposure on the liver, and to provide data for risk assessment methodology development.


  • Institute of Occupational Medicine (IOM) (UK)
  • University of Edinburgh (UK)
  • Helmholtz Zentrum München - German Research  Center for Environmental Health (Germany)
  • Università Ca' Foscari di Venezia (Italy)

Related Publications

  • Johnston HJ, Semmler-Behnke M, Brown DM, Kreyling W, Tran L, Stone V. (2010).Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro.Toxicol Appl Pharmacol.242(1):66-78
  • Zuin S, Micheletti C, Critto A, Pojana G, Johnston H, Stone V, Tran L, Marcomini A. (2011).Weight of evidence approach for the relative hazard ranking of nanomaterials.Nanotoxicology.5(3):445-58.
  • Johnston H, Pojana G, Zuin S, Jacobsen NR, Møller P, Loft S, Semmler-Behnke M, McGuiness C, Balharry D, Marcomini A, Wallin H, Kreyling W, Donaldson K, Tran L, Stone V. (2013). Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges. Crit Rev Toxicol. 43(1):1-20