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The

Nano-Safety Research Group

Specialists in the assessment of nanomaterial toxicity to human health and the environment

SAVE

SAVE:  Single-Administration Vaccine Enhancement

Funding:  BBSRC June 2018 - May 2021 £740k

Background:  In order to ensure a vaccine is effective in the long term, delivery of a vaccine booster is required at a predefined time (usually several months) after delivery of the initial vaccine.  Delivery of a booster for farm animals requires recollection of the animals and a second expensive visit by the vet.  By co-adiministration of the initial dose and the booster simultaneously the cost and effeciency is greatly enhanced.  This is relevant for a vareity of diseases such as Bovine tuberculosis (TB). In future, if successful, this approach can also be used in humans, especially in remote locations where booster take-up is low.

Goal:  To improve the efficiency of vaccinating farm and wild animals by administration of vaccines and their boosters simultaneously through use of a biodegradable, low toxicity implant the bursts to release the vaccine booster payload at a predefined time.